PPIs are one of the most powerful inhibitors of gastric acid secretion and one of the most common drug classes that are widely used to treat patients with disorders related to the upper digestive system. Therefore, we discussed the prevalence of proton pump inhibitors (PPIs) use and related factors in the Guilan cohort population.

In this cross-sectional study, which is the part of the Persian cohort study, 10,520 people aged between 35-70 in Guilan province referred to the cohort were examined in terms of PPIs consumption. These people were divided into two groups of consumers and non-consumers. Then these people in terms of demographic characteristics and clinical were compared. The data were analyzed using SPSS version 16 and STATA version 17 software. And the analysis was done and a significance level of 0.05 was considered.

The average age was 51.52 ± 8.90 years and 33.5% were older than 55 years and 53.5% were women. The prevalence of PPIs use in all participants was equal to 4.8% and was higher in women than men (6.1% compared to 3.3%). Overall, the prevalence of PPIs use increased with age of the participants. The chance of using PPIs in people aged 45-54 and older than 55 years was more. The chance of using PPIs in women was 1.89 times that of men. The chance of using PPIs was higher in widowed/deceased people. The odds of using PPIs were higher in illiterate people compared to people with university education. The chance of using PPIs was lower in working people. The chance of using PPIs was higher in people with high-risk level waist-to-hip ratio. Regarding physical activity the chance of using PPIs in people who were in the first tertile (low physical activity) and the second tertile (moderate physical activity) were more. Smoking decreased the chance of using PPIs by 26%. Similar results were found for hookah use and drug use. Having high blood pressure increased the chance of using PPIs by 94%; Also, having diabetes increased the chance of using PPIs by 64%. With the increase in the number of comorbidities, the chance of using PPIs increased, so that the chance of using PPIs in people who had one, two, and more than two comorbidities was 1.51, 2.50, and 4.81 times, respectively. The chance of using PPIs in people using NSADIs was 3.43 times that of people not using NSADIs.

In the majority of cases, we see that acid production inhibitors are used beyond the need. Explaining the possibility of excessive use of wound preventive drugs, perhaps due to the lack of complete knowledge of the indications for its prescription, unjustified fears of not prescribing drugs, lack of knowledge of the side effects of acid production inhibitors and their clear role in increasing microbial overgrowth and aspiration risks. It is respiratory. In addition to possible complications, medical and medical costs are also imposed on patients. But it is better to be careful at the beginning of the prescription and avoid inappropriate use of acid inhibitors.