Background: Chemokines such as stromal cell-derived factor 1 (SDF-1) and chemokine (C-C motif) ligand 28 (CCL28) play significant roles in tumor growth, angiogenesis, and metastasis. However, their serum levels in colorectal cancer patients have not been extensively studied.

Methods: We conducted a case-control study involving 100 patients diagnosed with colorectal cancer and 100 healthy control individuals. The control group was age and gender-matched to the patient group to eliminate potential confounding factors. Serum levels of SDF-1 and CCL28 were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using the Student's t-test to compare chemokine levels between the two groups.

Results: The serum levels of both SDF-1 and CCL28 were significantly increased in colorectal cancer patients compared to the age and gender-matched healthy controls (p < 0.05). Elevated levels of these chemokines suggest a potential association with tumor progression and metastasis.

Conclusion: Our findings indicate that SDF-1 and CCL28 are significantly upregulated in the serum of colorectal cancer patients when compared to age and gender-matched healthy individuals. These chemokines may serve as potential biomarkers for early detection and could be targets for therapeutic intervention. Further research is needed to explore their exact role in colorectal cancer pathology.